The expression 'making a run at' implies an effort to achieve or attain something. However, there are numerous antonyms that can convey the opposite meaning. Some possible antonyms for 'making a run at' include giving up, surrendering, abandoning, quitting, retreating, withdrawing, relinquishing, submitting, or capitulating. These words suggest a lack of determination, commitment, or persistence. When making a run at something, it usually involves pushing oneself to the limit to achieve a desired outcome, while the antonyms imply a lack of drive or willingness to succeed. Knowing the opposite meaning of a word can help in better understanding the context and communication.