The phrase "most beset" implies being surrounded or troubled by various difficulties. There are multiple synonyms that can be used to convey a similar meaning. The word "plagued" implies being troubled or constrained repeatedly by something. Another option is "embroiled," which suggests being involved in a difficult or complex situation. Synonyms such as "tormented" or "perplexed" also highlight the sense of being besieged or beleaguered. The term "harrowed" suggests being deeply distressed or tormented, while "afflicted" implies being burdened with a problem or illness. These words can be used to substitute for "most beset" to evoke a sense of difficulty or turmoil.