Most peewee refers to the smallest and the tiniest thing or person, but there are many antonyms for the word. Some of the antonyms for the word include substantial, considerable, or enormous. These words represent something that is large, significant, and substantial in size or amount. Another set of antonyms for most peewee are powerful, important, significant, or influential. These words represent something or someone that has a significant impact or role. For example, a powerful leader, an influential artist, or an important decision. These antonyms show that most peewee is not always the most appropriate word to use when describing things.