The phrase "most playedout" can be antonymized in a few ways depending on the context. If it's referring to a music genre or trend that's overused, some antonyms include "fresh," "innovative," and "original." If it's referring to a joke or punchline that's overused, antonyms might include "clever," "creative," and "unique." In general, antonyms for being "playedout" might include words like "new," "novel," "timeless," and "evergreen." Ultimately, the specific antonyms for "most playedout" will depend on the situation and the specific word or phrase being described.