Antonyms for the word "most well-worn" include "least worn," "seldom used," "infrequently traveled," "rarely touched," and "unexplored." These words suggest a sense of novelty and uniqueness, indicating that the object or place in question has not been used or visited by many people. These antonyms can be applied to various contexts, such as a pair of shoes, a hiking trail, or a book. Exploring less familiar paths or reading less popular books can broaden one's horizons and offer new perspectives. Thus, it is worthwhile to seek out alternatives to the most well-worn paths and experiences.