Re-calibrates refers to the process of adjusting or resetting something or bringing it back to its original, correct state. The opposite of re-calibrates would be de-regulates, which means removing or reducing regulations or restrictions. Other antonyms for re-calibrates would include disrupting, damaging, disarranging, dismantling or sabotaging. These words suggest that something is being altered or damaged, rather than being adjusted back to its original state. While re-calibrates suggests a positive action that enhances performance or efficiency, the antonyms for this word imply a negative action that hinders progress or causes dysfunction. Hence, it is important to understand the context and usage of such antonyms to convey the desired meaning accurately.