The antonyms for the word "re-freshes" include dull, exhaust, tire, weary, enervate, enfeeble, drain, weaken, and devitalize. These words convey a sense of tiredness, fatigue, and weakness that can make one feel drained of energy. Instead of making one feel revitalized and invigorated, these antonyms bring about a sense of lethargy and exhaustion. It is important to stay mindful of how one's actions affect their energy levels and to take steps to combat feelings of exhaustion and fatigue. Whether it's through exercise, meditation, or simply taking a break, finding ways to re-energize oneself is essential for maintaining good physical and mental health.