Sickle cell disease is an inherited blood disorder that causes red blood cells to become misshapen and stiff, leading to various complications like anemia and organ damage. There are various synonyms for sickle cell disease, including sickle cell anemia, hemoglobin S disease, and drepanocytosis. Sickle cell anemia is a term often used interchangeably with sickle cell disease, whereas hemoglobin S disease refers specifically to the genetic mutation that causes sickle cell symptoms. Drepanocytosis is another term used in some parts of the world to describe sickle cell disease. Regardless of the term used, sickle cell disease requires lifelong management and care to alleviate symptoms and prevent complications.