Sickle Cell Anemia is an inherited blood disorder that affects millions of people worldwide, mainly those of African descent. The condition causes red blood cells to become misshapen, leading to painful medical complications. Other synonyms associated with Sickle Cell Anemia include Sickle Cell Disease, Hemoglobin S Disease, and Sickle Cell Trait. Although Sickle Cell Anemia and trait are similar conditions, they have some differences. For instance, those with Sickle Cell Anemia have two copies of the abnormal hemoglobin gene, while those with Sickle Cell Trait have only one. It is essential that policymakers and healthcare providers create awareness and implement measures to manage and treat Sickle Cell Anemia to improve the quality of life of those affected by the condition.