The phrase "what upped" can be replaced with various synonyms, including "what's new," "what's happening," or "what's going on." These expressions are casual greetings and are commonly used to start a conversation with someone you haven't seen in a while, or just to check in on how someone is doing. Other synonymous phrases to "what upped" can be "how have you been," "what have you been up to," or simply "hey there." Regardless of the synonym used, they all serve the same purpose- to initiate communication with someone and show interest in their life.