The antonyms for the phrase "am at ease" are numerous, and they include phrases like "feel uneasy," "be nervous," "be uncomfortable," "be on edge," "be stressed," "be anxious," "feel tense," "be fidgety," "be restless," "be worried," "have butterflies in your stomach," and "be uptight." These phrases all describe a feeling of discomfort or unease that is often associated with anxiety, fear, or uncertainty. While being "at ease" is a state of comfort and relaxation, its antonyms describe a range of negative emotions that can make people feel uneasy, stressed, or anxious.