American Leishmaniasis is a parasitic disease caused by the Leishmania parasite found in the Americas. It is also known as cutaneous leishmaniasis or mucocutaneous leishmaniasis, depending on the location of the infection and the severity of symptoms. Other synonyms for American Leishmaniasis include Andean leishmaniasis, Rio de Janeiro leishmaniasis, Chiclero ulcer, espundia, and diffuse cutaneous leishmaniasis. The disease can manifest in various forms, from skin sores and ulcers to nasal and oral lesions that can lead to disfigurement and potential destruction of tissue. Without proper treatment, American Leishmaniasis can have severe consequences and should be promptly addressed.