When it comes to describing a state of ease or comfort, there are plenty of synonyms to choose from. One option is "relaxed," suggesting a sense of calm and absence of tension. "Comfortable" is another word that comes to mind, implying that a person feels at ease physically and emotionally. "At peace" is a more spiritual or mental state of ease, indicating a lack of stress or inner turmoil. "Free and easy" is a more casual and carefree way to express a state of relaxation. Ultimately, the right synonym for "are at ease" depends on the context and desired tone of your writing.