Being down and out refers to a state of extreme poverty or destitution. Its antonyms can be words that evoke a sense of prosperity and hope. Living comfortably is the opposite of being down and out. If someone is well-off, they have plenty of resources and are not struggling to make ends meet. Prosperity implies success and well-being, while penury suggests a lack of resources or hardship. In addition, we can use terms like thriving, flourishing, and successful to describe the opposite of being down and out. These words portray a sense of affluence, good fortune, and abundance, in stark contrast to the sense of hopelessness that characterizes being down and out.