When facing obstacles or challenges, we often use the phrase "comes up against". However, there are many other synonyms we can use to express the same idea. "Encounter" is a common synonym that means to unexpectedly come across a difficulty or obstacle. "Confront" is another option that implies a deliberate meeting of an issue head-on. Another word that can be used is "face" which is similar to confront, but may also suggest a more passive approach to dealing with the obstacle. "Encumbered" is another synonym that expresses the idea of being hindered by something. Finally, "enclosed" can also be used to signify that one is bounded or restricted by a difficult situation.