The antonyms of "pre-disposed" include "unaffected," "uninfluenced," "unwilling," and "neutral." When someone is not affected or influenced by a certain trait, event, or circumstance, they are considered unaffected. Similarly, if someone is not willing or ready to accept a certain idea or belief, they are considered unwilling. Lastly, if someone is neutral, it means they are not inclined towards any particular side, and are open to all possibilities. The antonyms of pre-disposed indicate a lack of predisposition or inclination towards something, and suggest a state of neutrality or resistance towards a certain idea or belief.