Tay-Sachs is a rare and fatal genetic disorder that affects the nervous system. It is primarily found in the Ashkenazi Jewish population, but can affect anyone regardless of ethnic background. The disorder is caused by a deficiency of an enzyme that breaks down a fatty substance called ganglioside. As a result, ganglioside accumulates in the brain and spinal cord, leading to the destruction of nerve cells and brain damage. Some synonyms for Tay-Sachs include GM2 gangliosidosis, hexosaminidase A deficiency, and infantile gangliosidosis. Currently, there is no cure for Tay-Sachs, but there are treatment options that can help manage symptoms and improve quality of life.