The word "up-shot" typically refers to the final result or consequence of something, and its antonyms are words that describe the opposite or contrasting outcomes. Some possible antonyms for up-shot could include the terms downside, misfortune, loss, failure, or setback. These words reflect situations where things have not turned out as planned, or when there has been a negative outcome that is markedly different from the expected or desired result. By considering the antonyms of a word like up-shot, we can gain a better understanding of the range and complexity of the different outcomes that can result from any given action or decision.