Being at ease can be described as feeling comfortable, tranquil, and secure. However, there are several antonyms for this phrase that depict feelings of discomfort, unease, and restlessness. For instance, one antonym could be 'anxiety,' which implies a state of worry and nervousness. Another antonym could be 'stress,' which conveys the feeling of tension and pressure. 'Discomfort' could also be an antonym, indicating a sense of unease or pain. Furthermore, 'disquiet' or 'unease' could also be antonyms, depicting a sense of restlessness or agitation. In essence, the antonyms for "being at ease" describe a range of feelings that are entirely opposite to feelings of tranquility and contentment.