By-way is a term that is often used to refer to a less traveled or less common route. However, there are several antonyms for the word by-way which refer to more commonly traveled routes. One such antonym is the term highway, which is the opposite of a by-way and refers to a large, well-traveled road. Another antonym for by-way is the term main road, which refers to a major thoroughfare that is regularly used by vehicles. Additionally, terms such as freeway, expressway, and motorway can also be used as antonyms for by-way, as they all refer to large, high-speed roadways that are typically used for long-distance travel.