De-contaminate is the process of removing or reducing contamination from a material, object or area. Antonyms for de-contaminate could include words like contaminate, pollute, taint, infect, putrefy, poison, and corrupt. These are all actions that involve introducing harmful substances or elements into a material, object or environment. While de-contamination is an important process in maintaining health and safety, we must also do our part to prevent contamination in the first place. Being mindful of our actions and the impact they have on the environment is crucial in helping to reduce the need for de-contamination.