The word "de-populate" refers to the reduction in the number of people or a decline in population. Antonyms for this term include "populate," which means to fill an area with people, animals, or other living creatures. Another antonym for "de-populate" is "increase," which refers to the growth or expansion of a population. Additionally, "repopulate" is a suitable antonym, which suggests repopulating an area that has experienced a decline in population. These antonyms present a positive outlook on the growth and expansion of populations and emphasize the necessity of maintaining and sustaining the population of any given area.