Nuke refers to destroying something with the use of nuclear weapons. Due to its negative connotation, there are many alternative words that can replace nuke in conversation. Some synonyms include annihilate, demolish, obliterate, and devastate. Other options include wipe out, eradicate, exterminate, or decimate. In a more casual setting, the word bomb could also be used in place of nuke. These words convey the same meaning without the negative associations that nuke carries. With a variety of synonyms available, it becomes easy to express important ideas without evoking negative emotions.