De-predate is the act of protecting or restoring something from damage or destruction caused by predatory animals or humans. There are several antonyms for de-predate, including depopulate, destroy, damage, harm, hurt, ruin, vandalize, and ravage, which all mean to cause harm or destruction. Conversely, to save, conserve, protect, preserve, or restore are words that are closely related to de-predate and mean to prevent damage or restore something to its original state. In conclusion, antonyms of de-predate describe actions that cause harm, whereas its synonyms promote actions of preservation and restoration.